Postdoc (f/m/x) – 3D Epigenome Evolution in Human Brain Development

102835

Full time

39 hrs./week

Munich

At Helmholtz Munich, we develop groundbreaking solutions for a healthier society in a rapidly changing world. We believe that diverse perspectives drive innovation. Through strong partnerships, we accelerate the transfer of new ideas from the lab to real-life applications, improving lives.

The Institute of Epigenetics and Stem Cells studies fundamental epigenetic mechanisms shaping development, evolution, and disease. We employ cutting-edge technologies — from single-cell multi-omics and deep learning to live-cell imaging and stem-cell–based organoid systems — to predict, observe, and manipulate epigenetic processes. Our lab and institute host an international team of researchers from more than 15 countries, and all work is conducted in English.

How did the human brain evolve its unique regulatory landscape?

The Bonev Lab at Helmholtz Munich is seeking an ambitious and creative Postdoctoral Researcher (f/m/x) to explore this question at the intersection of single-cell epigenomics, comparative genomics, and evolutionary neurobiology. This ERC-funded project aims to uncover how gene regulatory networks evolved across human and non-human primates during brain development, using novel single-cell multiomics methods developed in our lab.

Our campus in Munich — one of Europe’s top centers for biomedical research — offers an outstanding infrastructure and close links with leading institutions such as LMU, TUM, and the Max Planck Institutes. Munich offers a vibrant international research community, excellent living conditions, and easy access to the Alps and major European cities.

Your tasks

You will lead an integrative project combining experimental and computational approaches to:

Characterize the evolution of cis-regulatory networks across primate brain development using novel single-cell omics methods
Apply deep learning models to integrate multi-omics datasets and link epigenomic evolution to emerging phenotypes
Use high-throughput CRISPR perturbation screens in cerebral organoids to test the functional relevance of candidate elements

Your profile

PhD in the life sciences or a related field
Expertise in at least one (preferably two) of the following areas:
- Single-cell omics
- Comparative genomics
- Epigenetics
- Brain development and evolution
Strong publication record demonstrating scientific independence
High motivation, creativity, and drive for scientific excellence
Excellent communication skills in English (German is not required)

If you fulfill all the requirements, you may be eligible for a salary grade of up to E 13. Social benefits are based on the Collective Wage Agreement for Public-Sector Employees (TVöD). The position has an (initial) fixed term until 31.12.2027 but may be extended under certain circumstances.

Managing Director Mike Frieser:

„We believe that diversity is the key to groundbreaking research and innovative solutions. Our flexible working models and remote options create a supportive environment for balancing work and family life. For us, contributing to a healthier society in such an inspiring workplace is truly meaningful.“

Get to know us

Benefits

Career Development

Postdoc program, scientific training & career center with tailored offers

Family Support

On-site kindergarten, holiday care, care for the elderly

Health Promotion

Sports, company doctor, mental health initiatives

International Staff Service

Support with the relocation and integration process in Germany

Scientific Resources

State-of-the-art infrastructure and Core Facilities

Recreation

30 days annual leave, flexi days, plus public holidays

Career Development: Postdoc program, scientific training & career center with tailored offers
Scientific Resources: State-of-the-art infrastruture and Core Facilities
Recreation: 30 days annual leave, flexi days, plus public holidays
International Staff Service: Support with the relocation and integration process in Germany
Health Promotion: Sports, company doctor, mental health initiatives

Interested in applying?

If you have any questions, feel free to contact Dr. Boyan Bonev, +49 89 2180-71902, who will be happy to help.Informal discussions before applying are welcome.

Our recruiting is decentralized - your application will be reviewed directly by the specialist department in which you could work in the future.

More information about our application process

Please send your application only via our online application tool and with the following documents:

CV
Cover letter
Contact details for at least two referees
your future research plan (3 pages max.)
CV
Cover letter
Degrees/Diplomas/Certificates
Contact details for at least two referees

30.11.2025

If you have obtained a university degree abroad, we will require further documents from you regarding the comparability of your degree.Please request the Statement of Comparability for Foreign Higher Education Qualifications as early as possible.

We are committed to promoting a culture of diversity and welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion or age. Qualified applicants with physical disabilities will be given preference.

Learn more about diversity at Helmholtz Munich

Our commitment

Helmholtz Munich

Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)

Institute of Epigenetics and Stem Cells

Feodor-Lynen-Str. 21

81377 München

zur Stellenbörse Online application

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Postdoc (f/m/x) 3D Epigenome Evolution in Human Brain Development

Postdoc (f/m/x) 3D Epigenome Evolution in Human Brain Development