PhD Position - Project P01 "Protective and pathogenic antibody responses at barrier organs"

Institute for Inflammation Medicine

TheDFG-funded Research Training Group (RTG) 3095“Protective and pathogenic antibody responses at barrier organs” is a collaborative doctoral programme jointly organized by the University of Lübeck and Kiel University– two modern and research-intensive universities with strong profiles in medicine, molecular biology, and life sciences. Their study programmes have consistently achieved top rankings in the CHE Ranking, the most comprehensive evaluation of study programmes at German universities.

Immunological barrier organs such as the skin, intestine, and lungs are continuously exposed to commensal microorganisms, pathogens, and environmental allergens. As a result, infections as well as allergic and autoinflammatory disorders at these mucosal interfaces are frequent and represent a significant burden to public health. Antibody-mediated immune responses play a central role in maintaining homeostasis at these sites: they contribute to the control of pathogen invasion, the regulation of gut microbiota, and the initiation and modulation of allergic reactions, while also exerting regulatory functions that can downregulate inflammation.

The overarching goal of RTG 3095 is to elucidate the mechanisms by which B cell responses are initiated, maintained, and contribute to either immunoprotection or immunopathogenesis at these immunological barrier sites. To achieve this, the programme employs state-of-the-art experimental approaches, including single-cell sequencing,spatial transcriptomics, and advanced molecular and immunological techniques. Doctoral researchers will benefit from a structured 4-year training programme that integrates cutting-edge research with comprehensive training opportunities.

Start in our team

Within this framework, the subproject P01 “Allergenicity of IgE and IgG1 clonotypes in murine food allergy”,led by Prof. Rudolf Manz at the Institute for Systemic Inflammation Research (ISEF)https://isef-luebeck.de/en/meet-the-lab/manz-lab-3, University of Lübeck, is seeking a PhD Candidate to start onApril 1, 2026.The position is initially limited untilMarch 31, 2030****.

What we offer:

The salary will be based on the German E13 TV-L scale, if terms and conditions under collective bargaining law are fulfilled
Part-time employment currently 25 hours/week
Participation in the structured qualification programme of RTG 3095, including workshops, courses, and summer schools in state-of-the-art immunology related research.
A highly stimulating research environment with access to state-of-the-art technologies such as single-cell sequencing and spatial transcriptomics
Excellent opportunities for scientific networking and qualification in cutting-edge immunological research

Your tasks:

Conducting a doctoral research project withinP01, focusing on the mechanisms by which individual IgE clones drive murine food allergy and their clonal relationship to allergen-specific IgG able to inhibit IgE-mediated allergic reactions
Analysis and interpretation ofhigh-throughput datasets, e.g., generated by scRNA-seq
Active participation in the scientific programme of the RTG’s graduate training activities
Presentation and discussion of research findings within the research consortium

Your profile:

A Master’s degree (or equivalent)in the life sciences or a related discipline, fulfilling the formal requirements for enrolment as a doctoral candidate at the University of Lübeck
Excellent command of English
Experience with mouse models,flow cytometry, and molecular and cellular biology techniques, as well as knowledge of German, are advantageous
Motivation to apply bioinformatics approaches for the analysis of high-throughput datasets (e.g., scRNA-seq); experience with R or comparable statistical software is desirable
Strong motivation to contribute your own ideas to a dynamic, interactive research team and an independent, structured, and collaborative working style

Application:

Please submit your application until14th December 2025,indicating the reference number27550.

Please include the following documents with your application:

Amotivation letter(maximum one page), which also indicates if you are also interested in other projects within the RTG 3095 (a maximum of 3 projects)
Acurriculum vitae(including a list of publications, if applicable)
Certificatesand transcripts of your previous university degrees (BSc/MSc, including transcripts of records)
at leastone letter of recommendation
Names andemail addresses of twopotential references

Selection process

Application to this subproject of RTG 3095 is generally considered to be an application also to the other subprojects of RTG 3095. Separate application to another subproject is not required, but please indicate in your motivation letter your favored RTG3095 subprojects (see above, motivation letter).

Among the written applications, the most suitable candidates will be invited to a one-day symposium, which will take place in January 2026 in Lübeck, Germany.

For further information, please contact:

Prof. Rudolf Manz

ISEF Lübeck – Manz Lab

Email:Rudolf.Manz@uksh.de

Campus Lübeck

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PhD-Position - Project P01 "Protective and pathogenic antibody responses at barrier organs"

PhD-Position - Project P01 "Protective and pathogenic antibody responses at barrier organs"