Johannes Gutenberg-Universität Mainzuni-mainz.de
PhD student: Plant RNA Biology
- Standort
- Mainz
- Remote
- Vor Ort
- Anstellungsart
- Vollzeit
- Erfahrung
- Mid-Level
- Bereich
- Forschung & Wissenschaft
- Bewerbungsfrist
- 23.09.2026
Heute
The Wachter group at the Institute for Molecular Physiology (Faculty 10: Biology of Johannes Gutenberg University Mainz) investigates the molecular mechanisms and biological functions of alternative RNA splicing in plants.
Our recent work identified a structured mRNA element that regulates specific DEAD-box helicase genes and revealed their critical role in controlling alternative splicing. Intriguingly, these functions appear to be linked to unique C-terminal features of the respective helicases.
As member of an interdisciplinary and international research team, you will investigate the molecular mechanisms underlying the splicing-regulatory activity of these DEAD-box helicases, with a particular focus on the functional relevance of RGG motifs, subcellular localisation, and their potential involvement in phase separation. In collaboration with the Weinberg group (University Halle-Wittenberg), you will also explore how helicase targeting of pre-mRNA structural elements may intersect with the binding of splicing regulators to determine splice site choice. Your research will employ a multidisciplinary approach that integrates molecular biology, RNA biochemistry, cell biology, and plant physiology, with Arabidopsis thaliana as the primary model system. You will benefit from extensive expertise, various core facilities, and a completely new research infrastructure. The PhD project is funded by the DFG and can be integrated in the international PhD programme (IPP) in Mainz.
Your tasks:
- Applying state-of-the-art techniques for gene-specific and genome-wide analyses of RNA biology, including transcriptome-wide profiling of alternative splicing and mapping of protein-RNA interactions
- Employing in vitro and in vivo experimental systems to address different levels of complexity and advance our understanding of the biological functions
- Contributing to teaching activities for Bachelor’s and Master’s students within our group
- Assisting with organizational and administrative tasks
- Presenting your research findings in oral and written form, including conference contributions, reports, and manuscripts
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